Hexbio ® MCP ® Granules

• Made up of 6 unique MCP® BCMC® strains:
  • Lactobacillus acidophilus BCMC® 12130
  • Lactobacillus casei subsp BCMC® 12313
  • Lactobacillus lactis BCMC® 12451
  • Bifidobacterium bifidum BCMC® 02290
  • Bifidobacterium longum BCMC® 02120
  • Bifidobacterium infantis BCMC® 02129
• Each sachet comes with 30 billion cells/g
• Mild orange flavour
• Clinically proven for safety and efficacy on the finished product
• Registered and approved by MOH
• Internationally established in more than 10 countries
• Recommended by doctors and widely used in hospital settings
• Can be used as a monotherapy/adjunct treatment and for health maintenance
• Halal and GMP certified
• Free from gluten and other common allergens
• Suitable for vegetarians & those with lactose intolerance

Disruption of normal gastrointestinal (GI) function is a common consequence from many aspects of our modern lifestyle such as high stress levels, alcohol consumption, illnesses, surgery, infection and medications. Recent clinical studies indicates HEXBIO MCP Granule plays a critical role in improving stool frequency and stool consistency in chronic constipation^1,2,3, promotes faster return and recovery of gut function after abdominal surgery^4,5, aids in glycaemic control in people with type-2 diabetes^6,7, and has the potential to improve renal profile and liver function in humans^8,9. HEXBIO MCP Granule supplies an abundance of strain-specific microbial cell preparation (MCP) that stabilizes the intestinal barrier, stimulates cellular growth, activates mucus production, gut motility, and enhances overall immunity. HEXBIO MCP Granule is therefore, widely used to restore and maintain overall GI health. Common GI conditions includes constipation, diarrhoea (AGE, AAD), irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), gastro-esophageal reflux (GERD), dyspepsia, urinary tract infection and dysmenorrhea.

Indications/Uses

As a health supplement.

Dosage/Direction for Use

Adults: 1 sachet twice daily.

Children (1 – 12 years old): 1 sachet once daily.

Method of Administration

Can be taken orally before or after meal. Take directly or mix with room temperature water, juice, or milk.

Reference

1. Sanmugapriya Jayasimhan , Ning-Yi Yap , Yvonne Roest, Retnagowri Rajandram , Kin-Fah Chin; Efficacy of microbial cell preparation in improving chronic constipation: A randomized, double-blind, placebo-controlled trial. Clinical Nutrition 32 (2013) 928-934.
2. Y.A. GHAFAR, H. YAAKUP1, R.A.R. ALI1, S.A. SHAH; EVALUATION OF THE EFFICACY OF PROBIOTICS (MCP® BCMC® STRAINS) TREATING CONSTIPATION IN ELDERLY PATIENTS WITH MULTIPLE CHRONIC CO-MORBIDITIES: A RANDOMIZED CONTROL TRIAL. J Nutr Health Aging. 2020
3. Ibrahim A, Ali RAR, Manaf MRA, Ahmad N, Tajurruddin FW, Qin WZ, et al. (2020) Multistrain probiotics (Hexbio) containing MCP BCMC strains improved constipation and gut motility in Parkinson’s disease: A randomised controlled trial. PLoS ONE 15(12): e0244680. https://doi.org/ 10.1371/journal.pone.0244680
4. Liyana Zaharuddin1 , Norfilza Mohd Mokhtar , Khairul Najmi Muhammad Nawawi and Raja Affendi Raja Ali; A randomized double-blind placebocontrolled trial of probiotics in post-surgical colorectal cancer. BMC Gastroenterology (2019) 19:131
5. Chun Khui Tan, Suraya Said, Retnagowri Rajandram, Zhiqiang Wang, April Camilla Roslani, Kin Fah Chin; Pre-surgical Administration of Microbial Cell Preparation in Colorectal Cancer Patients: A Randomized Controlled Trial. World J Surg DOI 10.1007/s00268-016-3499-9
6. Somayyeh Firouzi, Hazreen Abdul Majid, Amin Ismail, Nor Azmi Kamaruddin, Mohd‑Yusof Barakatun‑Nisak; Effect of multi‑strain probiotics (multi‑strain microbial cell preparation) on glycemic control and other diabetes‑related outcomes in people with type 2 diabetes: a randomized controlled trial. Eur J Nutr DOI 10.1007/s00394-016-1199-8
7. Hasain Z, Mokhtar NM, Kamaruddin NA, Mohamed Ismail NA, Razalli NH, Gnanou JV and Raja Ali RA (2020) Gut Microbiota and Gestational Diabetes Mellitus: A Review of Host-Gut Microbiota Interactions and Their Therapeutic Potential. Front. Cell. Infect. Microbiol. 10:188. doi: 10.3389/fcimb.2020.00188
8. Somayyeh Firouzi1, Barakatun-Nisak Mohd-Yusof1, Hazreen-Abd Majid, Amin Ismail and Nor-Azmi Kamaruddi; Effect of microbial cell preparation on renal profile and liver function among type 2 diabetics: a randomized controlled trial. Firouzi et al. BMC Complementary and Alternative Medicine (2015) 15:433 DOI 10.1186/s12906-015-0952-5
9. Mohamad Nor, M.H.; Ayob, N.; Mokhtar, N.M.; Raja Ali, R.A.; Tan, G.C.; Wong, Z.; Shafiee, N.H.; Wong, Y.P.; Mustangin, M.; Nawawi, K.N.M. The Effect of Probiotics (MCP® BCMC® Strains) on Hepatic Steatosis, Small Intestinal Mucosal Immune Function, and Intestinal Barrier in Patients with Non-Alcoholic Fatty Liver Disease. Nutrients 2021, 13, 3192. https:// doi.org/10.3390/nu13093192